Glucose Clamp Technique is helpful to evaluate Insulin Resistance for Impaired Glucose Tolerance.

1. What is Insulin Resistance?

Nowadays, the number of diabetic patients is increasing all over the world. Insulin resistance is associated with lifestyle-related diseases and regarded as an indicator of how insulin affects human body.

Type-II diabetes has a close relation with insulin resistance which causes other diseases such as obesity, hyperglycemia after meal, hypertension, hyperlipidemia and arteriosclerosis. Finally, it causes renal disease, retinopathy, neuropathy, heart disease and so on. Therefore, a treatment to remove or reduce insulin resistance and find what critical problem exists is very important.

2. What is Glucose Clamp?

The principle of the glucose clamp is to infuse insulin and glucose to the patients continuously to keep them euglycemic hyperinsulinemic condition in order not to release the glucose from the liver, according to “Glucose Clamp Technique” by Dr. Ralph A. DeFronzo et al. The blood glucose controller, “Artificial Pancreas”, makes it possible to conduct glucose clamp automatically and accurately.